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When any large caloric deficit drives rapid weight loss, a portion of what comes off is lean mass muscle, connective tissue, organ mass, and the water they hold alongside the fat

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Clinical improvement was also observed in oxidative stress markers, with improvements in methionine levels (p=0.05), homocysteine levels (SAH, p=0.007) and the ratio of S-adenosylmethionine (SAMe) to SAH (p=0.007), indicating improvement with methylation at the cellular level and a decrease in oxidative stress in the body 2

Of the included papers, 16 were randomised control trials (RCT), five were single arm interventional studies, one was a non-randomised comparative interventional study and one was a phase IV clinical trial