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Enhanced Phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies

Dolma S, Lessnick SL, Hahn WC, Stockwell BR

US EPA (1976) Manual of chemical methods for pesticides and devices

This might cause serious side effects including heart problems, seizures, and vomiting Thyroid hormone

Higher body weight increases the volume of distribution and clearance modestly, but the magnitude does not warrant weight-based dose adjustment per FDA labeling