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Metformin enhances autophagy and reduces tau and amyloid- pathology in AD models, 382 while AICAR reduces -synuclein aggregation and improves motor function in PD models

As part of the glutamate-glutamine cycle, astrocytes and oligodendrocytes take up the neurotransmitter glutamate released from neurons at synapses, metabolize it to glutamine using GLUL, and then export it back to neurons, where glutamine is converted back to glutamate using glutaminase (GLS)

The resulting solution was added to S-Trap micros (Protifi) and centrifuged at 4,000 g for 1 min

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This use was associated with the production of short-chain fatty acids, such as acetate 40