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doi: 10.1124/dmd.113.053546

Notably, while total FOXO4 protein levels remained consistent between young and elderly men, a striking age-dependent shift in its subcellular localization was observed: FOXO4 predominantly resided in the cytoplasm in young Leydig cells but translocated to the nucleus in aged cells

Early placebo-controlled trials found that coenzyme Q 10 pretreatment (60-300 mg/day for 7-14 days prior to surgery) provided some benefit in short-term outcome measures after CABG surgery (38, 39)

Unlike hormonal compounds, discontinuation simply means return to baseline rather than below-baseline function

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