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PAGln is also a common toxin in CKD, significantly accumulating in CKD patients and associated with overall mortality and cardiovascular disease (129), linking gut microbiota metabolism, CKD, and cardiovascular complications

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In fact, using them together can be more effective for treating hyperpigmentation than using either one alone

[DOI] [PubMed] [Google Scholar] 139.Skrzydlewska E., Farbiszewski R