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We identified six biophysical properties that can be predicted from a sequence using the ProtParam module ( from the biopython Python package 45 : (1) the isoelectric point in neutral pH, (2) GRAVY (grand average of hydropathy) 46 , (3) the instability index 47 , (4) aromaticity, (5) the molar extinction coefficient and (6) molecular weight

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doi:10.1007/s00125-007-0753-6 Mohan V, Sandeep S, Deepa R, Shah B, Varghese C

(2) downregulation of macrophages activity/function [40]