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When considering which patients would be least suitable for treatment with semaglutide, the clinical experts deferred to the product monograph for absolute contraindications and patients with potential increased risk of adverse effects (e.g., history of pancreatitis, gallbladder disease, diabetic retinopathy, severe renal impairment, gastrointestinal conditions)

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This improved comfort may be related to: More balanced hormonal signaling (GLP-1 + GIP) GIP activity that may reduce GLP-1-related nausea Smoother appetite regulation at equivalent weight-loss levels Personalized dosing and slow titration are essential for both medications