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All currently available GLP-1 receptor agonist therapy in the UK is administered via subcutaneous injection, either as daily or weekly formulations

Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues