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So you get these questions What is the research telling us

While some of the services in the cost range indicated by the commenter have significant claims volume, we do not believe that there is a current need for an additional APC level given that the estimated geometric mean cost of the requested Level 3 APC would be significantly distinct from a cost perspective

This is where the concept of bioavailability the degree and rate at which a substance is absorbed into the living systembecomes critical