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Tesamorelin is a synthetic modified GHRH analogue clinically approved to reduce visceral adipose tissue (VAT), especially in HIV-associated lipodystrophy, with demonstrated drops in VAT of ~15-18% over 52 weeks

At the molecular level, it modulates the expression of over 4,000 human genes, roughly 6% of the genome, according to a 2012 Broad Institute Connectivity Map analysis published by Pickart, Campbell, and colleagues

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Kassim SA, Abbas M, Tang W, Wu S, Meng Q, Zhang C, Naeem S, Li X, Chen R (2020) Retrospective study on melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopic finding in Zhuhai Hospital, China