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IGF-1 LR3 is a modified form of insulin-like growth factor-1 that acts directly on IGF-1 receptors in peripheral tissue, bypassing pituitary control entirely

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miR-145 was also shown to modulate IGF-1 signaling pathway by directly targeting IGF-1R in HCC (Su et al., 2009), but its role other cancer remained unknown ( Amplified IGF-1/IGF-1R signaling has been associated with increased relative risk for development of colorectal cancer (CRC) as well as CRC metastasis, and resistance to chemotherapeutic drugs (Weber et al., 2002