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This starvation-like state has been tested in studies, with researchers noting the bodys natural response is a recover the weight lost, driving hunger and appetite and, fat regain occurs disproportionately faster than muscle

In addition to GIPs role in promoting lipid storage in adipocytes 140 , the GIP receptor (GIPR) is found in neurons of the ARC, dorsomedial nucleus (DMH), and paraventricular nucleus of the hypothalamus 141

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During the Semaglutide Treatment Effect in People with Obesity (STEP) clinical trial program, researchers observed consistent and clinically significant weight loss among participants