39,95 Prices may be subject to local taxes which are calculated during checkout Similar content being viewed by others Data availability The coordinates and structural factors have been submitted to the Protein Data Bank with accession codes 6O8L (C9S SqrR, reduced), 6O8K (wild-type SqrR, reduced), 6O8N (C9S SqrR, tetrasulfide form), 6O8O (SeMet C9S SqrR, disulfide form) and 6O8M (C9S SqrR, derivatized with TMAD)
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Based on Bonferroni correction, antioxidant biomarkers in our study did not significantly contribute to neurodegenerative diseases, but there were some notional correlations between ascorbate and ALS, and between albumin with PD
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Thus, astrocyte-regulated iron efflux impairment, microglial iron buildup, and iron-mediated GSH depletion create a self-reinforcing cycle that propels ferroptosis in AD
