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Therefore, a prospective registry study or randomized pragmatic trial that can measure all relevant information more accurately and ensure a more inclusive patient population may be necessary to further confirm these findings

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GIP enhances fat metabolism, improves insulin sensitivity in adipose tissue, and may protect against some of the nausea that pure GLP-1 agonists cause

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Theres anecdotal evidence suggesting that stopping the GLP-1 weight loss shot can lead to weight regain, though studies haven't fully explored whether behavioral support and lifestyle changes could help maintain results after treatment