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Clinical study protocols had participants take their last dose of semaglutide at least 3 days but no more than 10 days before starting tirzepatide

J Pharmacol And Exp Ther (2002) 300:95866

Side Effects : Both Mounjaro and Ozempic have similar side effect profiles, including gastrointestinal discomfort, but the dual action of Mounjaro may result in slightly more pronounced appetite suppression

[11] [46] The effect was also larger for the studies that were conducted in countries that did not have mandatory grain folic acid fortification

Its a major change to a rule that has had high-profile consequences over the past decade