Superposition of PF-06372222-bound crystal structure (containing the C347 6.36b F mutation), with crystal structure based molecular dynamic simulations of F347 shown in blue (500 ns) and of simulations C347 (6.36b mutated back to cysteine) shown in pink (500 ns)
The experiment was divided into a normal control group, a DSS model group, and a DSS+IGF-1 LR3 treatment group (with doses of 0.1mg/kg, 0.5mg/kg, and 1mg/kg, respectively, orally administered daily), and treated continuously for 7 days
Seek urgent medical attention (999 or A&E) if sweating occurs with severe chest pain, persistent severe abdominal pain (potential pancreatitis), confusion or loss of consciousness, or signs of severe allergic reaction
While their primary indications differ (Wegovy for weight management, Ozempic for type 2 diabetes, Mounjaro for type 2 diabetes with a recent weight loss indication via Zepbound), their core mechanisms of action and common side effect profiles share significant overlap
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