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Some people experience gastrointestinal side-effects including nausea, vomiting, constipation and diarrhea

doi:10.1124/pr.115.010629

532,557559 It has been argued that the ancestral role of MarR family proteins was to maintain physiological homeostasis by sensing and derepressing the expression of genes encoding efflux pumps for both toxic metabolites as well as unnatural xenobiotics

"Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes (SUSTAIN 5)"