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The New England Journal Of Medicine 2006, 355: 2308-2320

Based on the patient's poor prognosis due to extensive local tumor spread and the presence of distant cerebral and vertebral metastases and a high risk of neurological deficits associated with a resection of the thigh tumors, a removal was considered unjustified

This enables the cells to migrate from one area to another

Kadakia K, Krumholz H

This involves a negative pregnancy test before starting treatment, use of highly effective contraception throughout (noting that topiramate may reduce the efficacy of some combined hormonal contraceptives discuss suitable methods with your prescriber), and annual counselling with completion of a Risk Acknowledgement Form