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What the iPLEDGE Program Requires The FDA-mandated iPLEDGE Risk Evaluation and Mitigation Strategy (REMS) program requires prescribers to document ALT, AST, and triglycerides before initiating therapy and to repeat them periodically

This finding has direct implications for research protocol design: most published and structured study designs incorporate a rest period following the active phase to allow receptor sensitivity to normalize before any subsequent research cycle, rather than using continuous, uninterrupted administration

Who it tends to work well for: Patients looking for a short-term boost, particularly those who need early momentum to establish new habits

doi: 10.1093/jn/138.1.226S, 38

Target engagement is key