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It works by stimulating the growth of blood vessels and nerves, boosting the production of important structural proteins like collagen and elastin, and supporting the cells that build our skins framework

McCord JM (1993) Human disease, free radicals, and the oxidant/antioxidant balance

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Their implication in CIPN through the overload of Ca 2+ entry has been demonstrated (Hill and Oliver, PKC enzyme: Apart from the involvement of PKC on the induction of oxidative stress in neurons, both human and animal studies have linked this enzyme to several pain types through excessive Ca 2+ entry and cation channel activation (Carozzi et al., 2009)

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