Take deep breaths and relax during the injection
In older adults with type 2 diabetes, retrospective cohort studies have linked semaglutide to reduced muscle mass, declines in grip strength (especially in women), slower gait speed, and functional decline, with higher doses as an independent predictor of muscle loss
The slowing of gastric emptying with GLP-1RA treatment increases the propensity for retained gastric contents, which could increase the risk of aspiration during upper gastrointestinal endoscopy or general anesthesia
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Importantly, their study also found increased risk of gastrointestinal disorders, 5557 hypotension and syncope (some prior evidence of blood pressure-lowering 5860 ), arthritic disorders, nephrolithiasis (alternative medications may be relatively more protective 61,62 ), interstitial nephritis, and drug-induced pancreatitis (adverse events have been reported 63,64 ) associated with GLP-1 RA use
