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Transcription factor binding prediction analysis for differentially expressed genes suggested that SIRT3-induced transcriptional changes in aged HSCs was influenced by transcription factors that are involved in the establishment of chromatin accessibility at inflammation-trained loci, such as NF-B, FOS, JUN, GATA1, ATF family members, CREB1, EGR1 and STAT family members (Extended Data Fig

4 For example, ADA and KDIGO joint group has recommended that for patients with T2DM and CKD who do not achieve their glycemic target with metformin and/or an SGLT2i or cannot use them, a GLP-1RAs with proven cardiovascular benefit is recommended

Changing of DOAC regiment, adding antiplatelet agents, increasing statin dosage did not significantly reduce the odds of recurrence

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Lab results confirmed