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RAS/MAPK is one of the dominant cancer-initiating pathways and has a well-known impression in tumorigenesis by enhancing the survival and metastasis of cancer cells [115]

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Oxidative stress was quantified through ROS, nitrites, TBARS, total thiols, and the activities of SOD, CAT GPx, GST, and ALA-D, using spectrophotometric assays and fluorescence-based detection