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Modifying the carrier surface with targeting molecules such as aptamers or functional peptides can improve local drug retention and specificity in diseased cartilage or pathological synovial cells, while reducing potential adverse effects from systemic exposure

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Discussion According to this meta-analysis, AOMs resulted in significant weight loss while being used, followed by weight regain after treatment discontinuation

Pyroptosis is a novel inflammatory form of programmed cell death defined as gasdermin-mediated programmed necrosis (Shi et al., 2015, 2017)