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Moreover, PIP2 is a substrate for phosphoinositide 3-kinase (PI3K), forming phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a critical docking site for proteins in the insulin signaling pathway, including Akt (Protein Kinase B)
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Second, the research should focus on specific patient subgroups, such as those with pre-existing kidney disease or severe obesity, to clarify semaglutides renoprotective potential, given the lack of significant effects on renal outcomes in this study