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In the systematic review of clinical trials mentioned above, tirzepatide conferred the greatest risk of vomiting, RR 13.23 (95% CI 4.8536.09), whereas the risks for semaglutide (RR 4.21 [95% CI 3.584.95]) and orforglipron (RR 4.43 [95% CI 1.4513.56]) were similar (15)