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When the supply of amino acids is reduced, it affects the renewal of cells, which causes, in particular, the thinning of the dermis

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doi: 10.1016/j.autrev.2009.03.010

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There are speculations that non-pathogenic commensal microorganisms, which co-evolved with humans, have been a source of immunomodulatory signals for the human body (the old friends hypothesis), and now prevent the development of immune-mediated chronic diseases (the hygiene hypothesis), with the proper composition of the microbiome promoting the maintenance of the bodys immune balance (the biodiversity hypothesis) [1, 39, 53, 54]