Concurrently, PPIs, frequently prescribed to diabetic patients for gastroesophageal reflux disease management, impair protein-bound vitamin B12 release from dietary sources in the non-acidic gastric environment, with prolonged use ( 2 years) conferring a 65% increased risk of deficiency [159]
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Rather, it appears that the population in the Bradstreet et al study had a higher body burden of lead, mercury, and cadmium, perhaps because they were slightly older (6.2 yr, range 3 to 15 years) or more likely because they were from a different area of the country (across the US vs