Anyone with uncontrolled diabetes needs to monitor blood glucose very closely given the competing effects of GLP-1 agonism (glucose lowering) and growth hormone (potential glucose raising)
Another mechanism potentially involved in weight gain could be the leptin resistance [49]
The arginate salt form dramatically improves oral bioavailability compared to the acetate form (this detail matters, and most vendors get it wrong) Cycling Run 812 weeks on, then 48 weeks off
Sikiric, P., Kokot, A., Kralj, T., Zlatar, M., Masnec, S., Lazi, R., Lonari, K., Oroz, K., Sabli, M., Boljesic, M., Antunovi, M., Sikiri, S., trbe, S., Stambolija, V., Orekovi, B., Kavelj, I., Novosel, L., Zubcic, S., Krezic, I., krti, A., Jurjevi, I., Blagai, B., Seiwerth, S., & Stareini, M
Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex