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Annual Review of Biochem

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Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut

Many providers use Tesofensine as an add-on rather than a replacement because it helps increase energy expenditure while the GLP-1 continues appetite regulation

Hypoglycaemia: Whilst these agents are not expected to cause low blood sugar on their own, people with diabetes who are also taking insulin or sulfonylureas may be at increased risk of hypoglycaemia