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The most common adverse events (AE) reported included skin-related toxicities, dehydration, diarrhea, asthenia, rash, hyperglycemia, hypertension, neutropenia, thrombocytopenia, anemia, hepatic dysfunction, proteinuria (5658), and hearing loss (59, 60), with non-fatal SAE occurred in 5-25% of patients, as well as a few treatment-related deaths (61)