Semaglutide goes under the skin, not into muscle
You have a history of pancreatitis, gallbladder disease, kidney failure, or severe gastrointestinal conditions
Pregnancy, Contraception and Breastfeeding Guidance GLP-1 medicines are not recommended during pregnancy or while trying to conceive due to insufficient safety evidence
Palmiter, Norstedt, Gelinas, Hammer, Brinster, "Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice", Science, 222:809-814, 1983
Some pharmacies have marketed tirzepatide mixed with vitamin B12 as "personalized." Regulators have flagged this: testing found a chemical reaction impurity between tirzepatide and B12 that is not present in FDA-approved tirzepatide, and its safety is unknown