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Other significant risks include acute pancreatitis, hypoglycemia when combined with insulin or sulfonylureas, acute kidney injury (particularly in the setting of severe gastrointestinal symptoms), diabetic retinopathy complications, and gallbladder disease

This can manifest as generalised aches, particularly in weight-bearing joints such as the knees, hips, and lower back

Weekly or biweekly weigh-ins are generally recommended rather than daily measurements, as day-to-day fluctuations due to fluid shifts, dietary sodium intake, and hormonal changes can obscure the underlying trend

Injectable compounds can run longer, often matching the full Retatrutide protocol duration

Rotating injection sites (abdomen, thigh, upper arm) helps prevent local reactions and ensures consistent absorption