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10.3389/fphar.2014.00151 87 RonaldsonP

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pneumoniae lacks the capacity for endogenous GSH synthesis

For instance, the combination of artesunate with immunomodulators, including methotrexate, tretinoin, and azathioprine, elicited superior macrophage apoptosis compared to the individual administration of any of these drugs (247)

For example, many in vitro and murine models fail to fully capture the complexity of human tumor heterogeneity, immune responses, and stromal interactions, which are critical determinants of therapeutic outcomes