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In humans, women typically show greater responsiveness to GLP-1 receptor agonists compared to men, potentially due to estrogens potentiation of GLP-1 receptor signaling within reward-related and metabolic pathways in the brain (Hayes et al
However, in SURPASS-5, individuals on a background of insulin glargine and tirzepatide reported serious hypoglycemia (19%) more than individuals on a background of insulin glargine and placebo (13%) [14]
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The key learnings are crucial, and when taken together, may be the recipe for success that every manufacturer needs: Patients are playing a greater role in their care
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