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Its mechanism is completely different from any of the GH-axis peptides described above

These diseases were selected as representative models owing to distinct organ-specific manifestations and shared underlying mechanisms of immunometabolic dysregulation

While GLP-1 peptides activate only the GLP-1 receptor, Retatrutide engages GLP-1R, GIPR, and GCGR simultaneously

To this end, endorectal US (ERUS) has been utilized both as a diagnostic and therapeutic modality in the management of fistulizing Crohn disease