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Months 3-6: As weight loss slows and stabilizes, shedding gradually decreases

Novo Nordisk filed its New Drug Application with the FDA on 18 December 2025, based on data from the REDEFINE 1 trial

Within a few months of dedicated physical therapy, the vast majority of patients find themselves doing things they havent been able to do comfortably in years

However, GLP-1 receptor occupancy and downstream signaling may persist even as plasma levels drop, creating a lag between apparent drug 'wear-off' and loss of appetite suppression or glucose control