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Despite the fact that many synthetic compounds with antioxidant activity have been developed and applied as therapies for oxidative stress-related diseases, their effectiveness has been disappointing [16] (Figure 7)

[ UA effects on cellular redox balance also involve the glutathione system

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The activity of GSH protects DNA integrity by neutralizing harmful elements

To view or add a comment, sign in Ahead of print MALAT1 modulates granulosa cells ferroptosis and apoptosis through PAK2 upregulation in polycystic ovary syndrome Highlights MALAT1 controls ferroptosis in KGN granulosa cells, uncovering a novel lncRNA-driven cell-death pathway in ovarian physiology