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Collectively these findings demonstrate that in middle age, although GE2 treatment effectively reduces body weight in both sexes, females may be more sensitive to its blood-glucose regulating effects

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Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function

Beyond SCFAs and tryptophan metabolites, gut microbiota participate in bile acid metabolism, converting primary to secondary bile acids