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Hypothyroidism is diagnosed in patients with PWS with a prevalence ranging 472% [40, 41]
This explains the clinical pivot toward injectable and oral options that deliver predictable GLP-1 concentrations
Centrally, GLP-1 receptor agonists act on hypothalamic appetite centers to increase satiety and reduce food intake
The medications themselves are FDA-approved for specific indications (diabetes and/or obesity), but microdosing is an off-label dosing strategy used at physician discretion based on individual response and goals
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