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Decreased oral birth control effectiveness: GLP-1 medications, including semaglutide, can decrease the effectiveness of oral contraception because the stomach does not empty as quickly

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Preclinical research suggests that GLP-1 signaling may influence dopamine-related reward pathways, which could help reduce the motivational pull of alcohol

Jody Dushay, an endocrinologist at Beth Israel Deaconess Medical Center and assistant professor of medicine at Harvard Medical School, said she doesnt support the use of compounded GLP-1 drugs but also worries that restrictions could add new strain to the overall supply

However, Wegovy will enjoy a data advantage for the next few years until its competitors manage to catch up with their own outcomes trial readouts, which are not expected until Q4/2027