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Rapid weight loss affects leptin levels, thyroid function, and cortisol patterns

66 Notably, semaglutide and tirzepatide (GLP-1RA + GIPR agonist) have been approved for chronic weight management in non-diabetic obese patients due to its significant weight-reducing efficacy

Starting with liquid or semi-liquid protein reduces the gastric volume and mechanical distension that contributes to nausea

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Activated charcoal, while sometimes used to reduce bloating, can interfere with nutrient absorption and is best avoided on semaglutide