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DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes

This interaction between ghrelin and leptin in control of food intake is called "argentinian ghrelin-leptin tango" ( Fig

A 2025 review summarizing the sperm data noted that a randomized trial reported a modest improvement in sperm shape after 24 weeks of semaglutide, though other measures did not clearly change [1]

They found that even without causing weight loss, retatrutide had anti-tumor effects that were similar to the currently used (and incredibly expensive) immunotherapy.[ref] A 5-year mortality study in colon cancer patients showed that GLP-1 RA use decreased mortality risk by 60% in obese patients.[ref] Animal studies may show the mechanism

The American College of Physicians guidelines note that continued treatment is necessary to maintain weight loss, as discontinuation often leads to weight regain