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It also decreases SLC7A11 expression by lowering H2Bub1 levels through the nuclear translocation of the deubiquitinase USP7, thereby increasing ferroptosis sensitivity [99, 100]

Quick Answer: Tirzepatide does not directly cause gallstones, but its rapid weight loss effects increase gallstone risk, with clinical trials showing cholelithiasis in 2.5% of treated patients versus 1.0% on placebo

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Semaglutide and Tirzepatide medications are given once weekly as an injection into the subcutaneous fat of the arm, stomach, or thigh