When chemicals enter the body through inhalation, ingestion, or skin contact, they can disrupt normal bodily functions and lead to a range of health problems
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(2) References: Office of Dietary Supplements
Contemporary pharmacological research has demonstrated that the lipophilic active metabolites of Salvia miltiorrhiza , the tanshinone compounds, possess multifaceted neuroprotective effects, such as anti-inflammatory, antioxidant, anti-apoptotic, and BBB protective properties, which can alleviate the pathological progression of HACE ( in vivo and in vitro experiments has reported that Tan-IIA can prevent lipopolysaccharide (LPS)-induced brain damage by activating the Nrf2 signaling pathway and rescuing tight-junction proteins in microvascular endothelial cells, thereby inhibiting oxidative stress and inflammatory responses to protect the BBB ( in vitro cell-based experiment using the human BBB model has reported that Tan-IIA can safeguard the BBB against hypoxiareoxygenation injury, which is linked to leukocytes, by reducing leukocyte activation and curbing the harmful effects of leukocyte-generated substances ( Coptis chinensis is a perennial herb of the Ranunculaceae family and its dried rhizome is used medicinally for its anti-inflammatory, antibacterial, and detoxifying activities
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