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Description

Case 13-2012

High throughput screening of millions of compounds across diverse chemical space is a starting point

The magnitude and severity of age-associated mitochondrial impairment in these organs becomes clear via the molecular data which shows that old mice had abnormalities in mitochondrial biogenesis and energy metabolism (PGC1), and impaired mitochondrial -oxidation of fatty-acids (PPAR), ATP synthesis (ATP5A), and mitophagy (PINK1)