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Aim for at least 1,200 calories daily for women and 1,500 for men, prioritizing protein (0.7 to 1.0 grams per pound of body weight)

Brain Boost GLP-1 users had a lower risk of memory problems like dementia and Alzheimers disease

While there are clear advantages to enrichment approaches to clinical trials, a tradeoff worth noting is the potential impact on the generalizability of the findings to a broader population (FDA, 2019b), which needs to be factored into decision making

This design choice introduces potential bias, particularly for subjective outcomes, but it reflects the practical reality that these treatments have different injection devices and titration schedules that would make blinding extremely difficult