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in 2003

mean age 40[SD 11.1], 59% female): 37 presymptomatic mutation-carriers (no symptomatic ICH), three symptomatic mutation-carriers (one symptomatic ICH), eight 50%-at-risk participants and 18 controls Among 37 presymptomatic mutation-carriers, 23(62%) had WMH in a multi-spot pattern, 28(76%) severe CSO-EPVS, 17(46%) microbleeds, and 8(22%) macrobleeds

(PubMed) Khajehdehi P, Pakfetrat M, Javidnia K, et al

At the 5mg dose, 85% of participants lost at least 5% of their body weight