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The broader comparison between retatrutide and mazdutide or survodutide and tirzepatide shows how the next generation of multi-receptor agonists is expanding the landscape

In long-term follow-up, the concomitant use of corticosteroids significantly increases the risk of infections [346], and very rare cases of multiple immune modulation-related malignancies have also been reported [341]

Standardized evaluation frameworks for redox responsiveness, degradation kinetics, and toxicity remain underdeveloped

These interventions are aimed at the consequences of the disease, rather than targeting its cause

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