Patients should contact their GP or prescribing clinician if they experience: Severe or persistent cramps that do not respond to simple measures or significantly impact daily activities and sleep quality Frequent cramping occurring multiple times daily or nightly Associated symptoms such as muscle weakness, numbness, tingling, or changes in sensation, which may indicate neurological involvement Visible muscle changes including swelling, redness, tenderness, or asymmetry between legs Signs of dehydration such as dizziness, reduced urine output, dark urine, or confusion These features may indicate underlying conditions requiring investigation, such as significant electrolyte disturbances, peripheral neuropathy (particularly relevant in diabetes), peripheral arterial disease, or, rarely, more serious muscle disorders
These medications may benefit patients with metabolic liver disease regardless of diabetes status, especially if metabolic risk factors are present
When initiating GLP-1 therapy, patients should be aware of potential side effects
Semaglutide is a safe and effective way to help folks lose weight, but it has some side effects: nausea, diarrhea, constipation, and abdominal discomfort
But where brand names like Wegovy and Saxenda are solely focused on mimicking GLP-1 receptors, tirzepatide targets both GLP-1 receptors and another gut hormone known as GIP